We are now just weeks away from Origin One and NSW eligible players are dropping like flies.

Latrell Mitchell has long been ruled out while Ryan Papenhuyzen's recent injury has robbed him of a near certain Origin debut.

Origin mainstay Cameron Murray joins the aforementioned stars in the casualty ward following a serious injury. He was certain to run out for the Blues on June 8th.

Murray's loss will be someone else's game, with both Origin second row spots up for grabs.

Looking at the list of names there are plenty of options but I certainly wouldn't want to be in Brad Fittler's shoes come selection.

Below are the players most likely to run out to represent New South Wales in the Series opener in Sydney.

4. Tyson Frizell

After missing out on last year's Origin Series through injury, Newcastle's Tyson Frizell will be keen to feature in yet another Origin tilt.

Frizell is back into the Knights setup after missing two weeks through injury. A couple of big performances over the next fortnight and Frizell is surely playing yet another Origin.

Averaging over 100 metres per game and tackling at almost 95%, Frizell's numbers are perfect for the brutality of Origin.

The Knights superstar has enjoyed a brilliant Origin career to date. Even in defeat he was often in the Blues' best forwards.

Frizell never lets anyone down, tackles as though his career depends on it and can find the try line.

I would be shocked if he is not named somewhere in the squad but right now I'd be leaning toward partnering Frizell with Liam Martin as the run on second rowers.