The Roosters have won three of their past four games, and look set to name the same 17 once again for the fourth straight week after getting through Friday's 28-10 win over Cronulla unscathed.
South Sydney will be hopeful winger Richie Kennar returns from a hamstring injury, which would likely see Dane Gagai shifted to fullback, meaning Hymel Hunt would be left out.
Adam Reynolds in under a concussion cloud, but will be named and should be fit to play on Thursday.
The Storm don't have any injury issues, although form may be the cause for change for Craig Bellamy.
Halfback Brodie Croft failed to fire once again on Saturday against the Tigers, with young reserve Ryley Jacks knocking on the door to replace him.
“It certainly wasn’t one of his best performances. He’s only a young kid and he’s still learning and basically in all of our games this year, he’s been under pressure. It hasn’t been an easy learning curve for him," Bellamy said about Croft following the Storm's round five loss.
For Newcastle, Mitch Barnett will miss after being handed a one-week ban, although that should see Jacob Saifiti come straight into the 17.
Why make a change if you're the Dragons? St George don't have any injury concerns and have started the season five from five, with Paul McGregor set to name the same 17 for their clash with the Sharks.
Cronulla coach Shane Flanagan has a tricky decision on his hands, regarding the position of stars Josh Dugan and Matt Moylan.
Dugan is set to return from injury this weekend, although Moylan was impressive in the No. 1 jersey last time out.
Flanagan can either opt to play both in the backline, or allow Moylan back to No. 6 and hand Dugan the fullback role.
The Sharks will also be sweating on the fitness of James Segeyaro and Andrew Fifita, who must both pass concussion tests in order to play.
The Warriors are the only other undefeated side in the competition and will stick with the same side from round five, while Brisbane coach Wayne Bennett believes he'll keep the same 17 despite the Broncos starting the season 2-3.
The Cowboys don't have any injuries or suspensions to worry about, although Paul Green could make a change at fullback, with Lachlan Coote pushing for selection ahead of Ben Hampton after two games in reserve grade.
Bulldogs back-rower Josh Jackson could potentially miss the next two matches as he contests his dangerous contact charge at the judiciary.
Jackson could have accepted a one-match ban but is fighting the charge. Adam Elliott is expected to shift to the right edge, while Greg Eastwood or Danny Fualalo are expected to play lock.
Canberra halfback Sam Williams will miss the next 4-6 weeks with a knee injury, and will be replaced in the side by Blake Austin.
Ata Hingano, Michael Oldfield and Aidan Sezer will all be named despite suffering concussions on the weekend, and should all be fit to play.
For the Eels, Clint Gutherson will make his long awaited return to the NRL since rupturing his ACL last July, and will take over from Will Smith at fullback.
Bevan French and Kane Evans should be fit enough to return, while Parramatta will be sweating on the fitness levels of Nathan Brown, Kirisome Auva'a and Tepai Moeroa.
Waqa Blake will miss the next month of football with an ankle injury, but could be replaced by Dallin Watene-Zelezniak if he is cleared to return from a broken jaw.
Gold Coast will be without forward Ryan James after he was handed a one-week suspension with an early plea for a hit on Manly's Lachlan Croker last weekend.
Tom Trbojevic will return to fullback this weekend, with Jonathan Wright set to be the unlucky man to make way after a reshuffle in the backline.
Lachlan Croker will need to pass a concussion test to play.
For the Tigers, Russell Packer will likely miss the next month with a knee injury. Josh Reynolds should be fit to play, although coach Ivan Cleary will need to open a spot for him given Benji Marshall's currently form.
Elijah Taylor is also expected to make a return from a hamstring injury.