The Cronulla Sharks will face a nervous wait with Paul Gallen, Andrew Fifita, Wade Graham and Luke Lewis all injured in the loss to the St George Illawarra Dragons.
Gallen was the first forced from the field after injuring his knee in an awkward tackle.
Early reports suggest Gallen might have suffered a medial ligament strain which could see him sidelined anywhere from 2-10 weeks.
Fifita, on the other hand, could be facing a longer stint on the sidelines with fears he might have suffered an ACL injury.
An ACL injury would see Fifita miss the rest of the season.
To compound the injury crisis at Cronulla, star forwards Wade Graham and Luke Lewis also failed to finish the match.
Graham appeared to have a hamstring injury, while Lewis reportedly suffered a cork to his leg.
All four players will be sent for scans to ascertain the extent of the injuries.