Friday Night, ANZ Stadium
South Sydney will look to get back on the winner's list and keep their finals hopes alive with a win against an Origin-hit Gold Coast side on Friday night.
Souths were gallant in defeat last week against the Broncos but lacked the firepower to seriously trouble Wayne Bennett's side.
They'll go into this clash with an unchanged lineup and start as heavy favourites with the Titans missing Jarryd Hayne and Nathan Peats to Origin duty.
To make matters worse for the Titans is that Jarrod Wallace is also out due to Queensland commitments while backup hooker Karl Lawton is out through injury along with Tyrone Roberts and Kane Elgey.
They still have Ash Taylor in the halves, paired with Chris McQueen in a little bit of a surprise, with Will Zillman slotting in at fullback at Pat Politoni in the number 9 jersey.
A bit of a makeshift side could cause headaches for the Rabbitohs, as we know the Titans will throw all they have as they also look to keep their season alive.
However, the experience of John Sutton, Adam Reynolds and the Burgess brothers should be enough for Souths to get the chocolates.
Souths by 10.
Saturday Night, AAMI Park
In a slightly questionable fixturing mishap by the NRL, two of the league's heavyweights will go toe to toe without their superstar players.
Billy Slater, Cameron Smith, Cooper Cronk, Cheyse Blair, Jordan McLean, Will Chambers and Tim Glasby will all be sidelined for the Storm through injury or Origin duty while Coen Hess, Johnathan Thurston, Gavin Cooper and Michael Morgan will be representing the Maroons next week, meaning they won't make the trip down south.
The absentees for the Storm means Young Tonumaipea will fill Billy Slater's role at fullback with youngster Curtis Scott and Tohu Harris donning the three and four jerseys.
Ryley Jacks gets the start at halfback alongside Cameron Munster, with Slade Griffin playing at hooker.
The Storm's forward pack is still very strong, with the Bromwich brothers, Nelson Asofa-Solomona and Felise Kaufusi heading that line in what will go a long way to extending their lead atop the NRL ladder as they'll run into Jason Taumalolo, Ethan Lowe and Scott Bolton, who are a reasonable trio in their own right.
Kyle Laybutt will assume five-eighth responsibilities alongside Ray Thompson in the halves. Expect John Asiata to be given more of a green light with the ball in hand as well.
The Storm are favourites with the bookies and you can expect Cameron Munster to have a big game as he continues to excel in his new role in the halves however the slightly more stable Cowboys will certainly be knocking on the door.
Storm by 4.
Saturday Night, Southern Cross Group Stadium
The premiers continued their unusually poor run of form at home last week, going down to the Storm as their bitter rivalry continued.
They'll be out to right those wrongs this weekend against a struggling Tigers side missing their key Origin duo in Aaron Woods and James Tedesco.
The Sharks have Origin representatives of their own, however, with Andrew Fifita, James Maloney, Jack Bird, Valentine Holmes and Wade Graham all selected for game two.
The changes sees Gerard Beale slot in at fullback with Edrick Lee and Fa'amnu Brown join the back line while Jayson Bukuya gets a start in the second row.
Luke Brooks returns for the Tigers which will give their fans some hope as Tuimoala Lolohea looks to improve on his start with his new club.
Despite missing a host of big names, the Sharks are still filled with talent as Luke Lewis - continuing his strong run of form - and Paul Gallen will make any side formidable.
Offensively, the Sharks have struggled at times in 2017, however, their defence should do enough to blanket the Tigers' league-worst attack.
Sharks by 6.
Sunday Afternoon, ANZ Stadium
The return of Corey Norman failed to spark the Eels into action last week however they'll need their star half in full flight as they come up against Gareth Widdop and the Dragons.
Norman's return meant the in-form Clint Gutherson was shifted to the centres as the former's pairing with Mitchell Moses will prove crucial to the Eels finals chances.
Kirisome Auva'a starts on the wing in place of Nathan Davis in the only change to the side to take on a Josh Dugan and Tyson Frizell-less Dragons.
The Dragons were disappointing last week against the Dogs, and having lost two out of their last five, their hot start to 2017 could be forgotten should they continue to slide.
They're still well entrenched in the top eight for the time being at least, which may buy them some time to rediscover their early season form. Jason Nightingale reverts to fullback this week as the Dragons look to rediscover their attacking flair.
The Eels sit on the cusp the eight and will start as favourites as they look to bridge the gap in the second half of the season. As an important game in the context of both teams season, this is proving to be a cracker of a contest.
Dragons by 2.