All 16 teams are in for Round 5, and with injuries and suspensions causing chaos, there are plenty of changes and talking points.
Here are all the big ones.
ROUND 5 TEAMS IN FULL
Canberra Raiders
Cronulla Sharks
- Kayal Iro has a hamstring injury, so he is out of this weekend's trip south. Back-up centre Mawene Hiroti comes into the side.
- Tom Hazelton has been named to return from a back injury again. He takes the place of Siosifa Talakai who is out with concussion.
- Billy Burns remains on the reserves list despite Talakai's absence.
Penrith Panthers
North Queensland Cowboys
- The Cowboys have had their first win of the year, and evidently, Todd Payten sees no reason for change.
- Still no room for Zac Laybutt who is on the comeback trail from an ACL. He is in jersey 19 this week.
South Sydney Rabbitohs
Sydney Roosters
Parramatta Eels
- In a big boost for Parramatta, Dylan Walker joins the club and goes straight onto the bench.
- Luca Moretti also joins the bench.
- Charlie Guymer drops out, but maybe more intriguingly, Joey Lussick has been dropped. Ryley Smith will move from the bench to dummy half.
- No other changes for the Eels, who still have a host of talent in the NSW Cup.
St George Illawarra Dragons
- After being a late inclusion to the run on side last week, David Klemmer stays in the starting side.
- The man he swapped spots with, Toby Couchman, takes the other starting spot with Emre Guler out suspended.
- The vacant spot on the bench is claimed by Blake Lawrie although Loko Pasifki Tonga in jersey 19 is getting closer to a debut.
Gold Coast Titans
- Jaimin Jolliffe is back from a calf injury after two weeks out.
- Iszac Fa'asuamaleaui is out with an ankle injury, and Sam Verrills with a hip strain.
- Jolliffe joins the bench for Fa'asuamaleaui, while Chris Randall promotes from the bench to hooker with Verrills out.
- Sean Mullany is the debutant on the bench for the Titans to take the vacant spot.
- Josiah Pahulu is in the NRL squad as a reserve for the first time this year, wearing jersey 22.
The Dolphins
- Tom Gilbert it out suspended. The Dolphins have a ready-made replacement in Max Plath, who shuffles from the edge to the middle, a role he played for much of last year.
- Connelly Lemuelu joins the second-row after missing recent weeks with an eye injury.
Brisbane Broncos
Wests Tigers
- Jarome Luai is out suspended. Latu Fainu comes straight into the starting side after playing a host of positions last weekend from the pine.
- Adam Doueihi pulled out in the warm up last weekend with a groin injury. He has been named to play this weekend.
- Jack Bird, who was his late replacement at centre, goes back to the bench.
- Solomona Faataape had a poor performance against the Warriors and has been dropped, with exciting youngster Luke Laulilii into the side.
Manly Sea Eagles
Melbourne Storm
- Tyran Wishart's poor effort against the Dragons hasn't seen him lose his spot. He remains at halfback.
- Jahrome Hughes is named among the reserves, so is close to returning.
- If Hughes does return, Wishart would likely drop to the bench with Bronson Garlick shuffling out of the side.
- Marion Seve was a late inclusion on last week's bench, but he is out this week with Lazarus Vaalepu named on the bench.
- Moses Leo has been named among the reserves.
Canterbury Bulldogs
- Sitili Tupouniua is out with a suspension, with Kurtis Morrin, who was a late out last week, taking his spot on the bench.
- Morrin's replacement from last weekend, debutant Jack Todd, stays on the pine.
- Jacob Kiraz wasn't due to return for a number of weeks, but is getting closer, named on the reserves for Round 5.
Newcastle Knights
- Forward pack leader Leo Thompson is back in the starting side for Newcastle. A straight swap sees Brodie Jones drop back to 18th man.
- No other changes for the Knights, with the likes of Matthew Arthur and Jackson Hastings still on the reserves list.