Penrith prop Reagan Campbell-Gillard has suffered an undisplaced fracture of the mandible, and will miss at least the next four to six weeks.
The 24-year-old will see a surgeon next week, and will search for the best recovery option.
Campbell-Gillard collided with Sydney forward Jared Waerea-Hargreaves in the opening half, and left the field in the 21st minute for a head injury assessment, although his injury was later diagnosed as a jaw problem.
The forward is now ruled out of next Sunday's Origin II, after making his debut in Origin I.
He will also be in doubt for Origin III on July 11.