The Penrith Panthers come into the 2025 NRL season looking to make it five premierships on the bounce, but it will be a less than straightforward run through the season.

Here is everything you need to know about the Panthers' fixture list for the upcoming season.

Teams to play twice
Sydney Roosters (Round 2, 7), Melbourne Storm (Round 3, 24), South Sydney Rabbitohs (Round 4, 20), North Queensland Cowboys (Round 5, 10), Newcastle Knights (Round 12, 23), Parramatta Eels (Round 13, 19), Wests Tigers (Round 14, 21), Canterbury Bulldogs (Round 17, 26)

When the mathematics of fixture list toughness is run, it's impossible for the Panthers to have the toughest draw given they can't play against themselves.

Despite that, they do have to play the Melbourne Storm and Sydney Roosters out of last year's top four, although the Roosters are likely to go in the wrong direction this year.

They also clash with the Cowboys, Knights and Bulldogs out of last year's top eight, with their other double ups coming against the Eels, Rabbitohs and Tigers.

Travel schedule
The Panthers face a tricky start to the season when it comes to travel, with a trip to Las Vegas on the menu after the shortest off-season of any team given their appearance in the grand final.

They also then have to travel as much as any Sydney-based team over the remainder of the season, with another six games requiring air transport during the year.

They face a trip to Melbourne, a trip to Auckland, a trip to Townsville, one to the Gold Coast and two to Brisbane.

NRL Grand Final - Storm v Panthers
SYDNEY, AUSTRALIA - OCTOBER 06: Isaah Yeo and Nathan Cleary of the Panthers hold aloft the Provan-Summons Trophy after winning the 2024 NRL Grand Final match between the Melbourne Storm and the Penrith Panthers at Accor Stadium on October 06, 2024, in Sydney, Australia. (Photo by Quinn Rooney/Getty Images)

Turnaround times
The Panthers also have been dealt the rough end of the stick when it comes to turnaround times throughout the 2025 season.

They face two five-day turnarounds, both coming in and around the State of Origin period. The first is in the full round between Game 2 and 3, and the other is the week after the Origin period finishes.

Certainly less than ideal for the Panthers who will have plenty of players in the Origin arena.

The club also have half a dozen six-day turnarounds, with three of those coming in the final five weeks of the season, creating a chaotic finish to the year for the men from the foot of the mountains.

Start of the season
The Panthers open their season in Las Vegas against the Cronulla Sharks in what should be a bell-ringer of a clash. They then face the Roosters and Storm (away from home), before the Rabbitohs, Cowboys and Dolphins round out their first six games.

The opening to the year will certainly give plenty of insight into how Penrith are going to perform following the off-season departures of Jarome Luai, Sunia Turuva and James Fisher-Harris, with tough opposition littered through the start of their campaign.

The Origin period
Few teams are hit as hard by State of Origin as the Panthers.

In a boost, they have landed two of their byes before Origin games though, with the Panthers not having to play before Game 2 or 3.

They clash with the Knights before Game 1, while their games after Origin with players backing up on tight turnarounds feature the Eels, the Warriors in Auckland, and the Eels again.

2023 NRL Grand Final - Panthers v Broncos
SYDNEY, AUSTRALIA - OCTOBER 01: Nathan Cleary of the Panthers celebrates scoring a try during the 2023 NRL Grand Final match between Penrith Panthers and Brisbane Broncos at Accor Stadium on October 01, 2023 in Sydney, Australia. (Photo by Bradley Kanaris/Getty Images)

The run home
The Panthers have a run home that most clubs would dream of. In the final seven weeks, the only teams they face from last year's top eight are the Knights, Storm and Bulldogs.

Their other games during that period come against the Tigers, Titans, Raiders and Dragons, with the Panthers also only leaving New South Wales once in that period - during Round 22 against the Titans.

Toughest stretch
The period leading into the Origin window could be a tough one for the Panthers, with the Sea Eagles, Broncos (at Magic Round) and Cowboys in Townsville off a six-day turnaround leading into their first bye of the season.

Given their heavy weight of travel during the first six weeks, as well as some of the tough opposition they play, this could be a physically demanding stretch for the Panthers.

Easiest stretch
The period directly after State of Origin is over should be one where the Panthers can build a head of steam.

Round 20 against the Rabbitohs is on a five-day turnaround, but after that, they have eight days before playing the Tigers at home, seven before playing the Titans, and another six before playing the Knights.

Games to watch
Round 1, vs Cronulla Sharks, at Allegiant Stadium, Sun, Mar 2, 3:30pm
Round 3, vs Melbourne Storm, at AAMI Park, Thu, Mar 20, 8pm
Round 8, vs Manly Sea Eagles, at CommBank Stadium, Sat, Apr 26, 7:35pm
Round 19, vs Parramatta Eels, at CommBank Stadium, Sun, Jul 13, 4:05pm
Round 26, vs Canterbury Bulldogs, at Accor Stadium, Thu, Aug 28, 7:50pm

The must-win games
Round 2, vs Sydney Roosters, at CommBank Stadium, Fri, Mar 14, 8pm
Round 6, vs The Dolphins, at Suncorp Stadium, Thu, Apr 10, 7:50pm
Round 21, vs Wests Tigers, at CommBank Stadium, Sat, Jul 26, 5:30pm
Round 23, vs Newcastle Knights, at McDonald Jones Stadium, Fri, Aug 8, 6pm
Round 27, vs St George Illawarra Dragons, at WIN Stadium, Sat, Sep 6, 3pm

Full fixtures

Round Opponent Date Time (AEDT) Venue
1 Sharks Sun, Mar 2 3:30 pm Allegiant Stadium
2 Roosters Fri, Mar 14 8:00 pm CommBank Stadium
3 Storm Thu, Mar 20 8:00 pm AAMI Park
4 Rabbitohs Thu, Mar 27 8:00 pm Accor Stadium
5 Cowboys Fri, Apr 4 6:00 pm CommBank Stadium
6 Dolphins Thu, Apr 10 7:50 pm Suncorp Stadium
7 Roosters Sat, Apr 19 7:35 pm Allianz Stadium
8 Sea Eagles Sat, Apr 26 7:35 pm CommBank Stadium
9 Broncos Sun, May 4 4:05 pm Suncorp Stadium
10 Cowboys Sat, May 10 7:35 pm Queensland Country Bank Stadium
11 Bye
12 Knights Sat, May 24 5:30 pm Carrington Park
13 Eels Sun, Jun 1 4:05 pm CommBank Stadium
14 Wests Tigers Sun, Jun 8 4:05 pm CommBank Stadium
15 Bye
16 Warriors Sat, Jun 21 3:00 pm Go Media Stadium
17 Bulldogs Thu, Jun 26 7:50 pm CommBank Stadium
18 Bye
19 Eels Sun, Jul 13 4:05 pm CommBank Stadium
20 Rabbitohs Thu, Jul 18 8:00 pm CommBank Stadium
21 Wests Tigers Sat, Jul 26 5:30 pm CommBank Stadium
22 Titans Sat, Aug 2 3:00 pm Cbus Super Stadium
23 Knights Fri, Aug 8 6:00 pm McDonald Jones Stadium
24 Storm Thu, Aug 14 7:50 pm CommBank Stadium
25 Raiders Fri, Aug 22 6:00 pm Glen Willow Oval
26 Bulldogs Thu, Aug 28 7:50 pm Accor Stadium
27 Dragons Sat, Sep 6 3:00 pm WIN Stadium