Entering Round 6, some NRLÂ clubs are set to receive significant boosts to their team, while others have lost key players as they look to clinch the two points.
Some big additions this week include Reece Walsh, Josh Addo-Carr and Zac Hosking, while Latrell Mitchell, James Tedesco and Dominic Young headline the losses.
Teams will be named on Tuesday at 4pm (AEST), but here is all the latest in news and rumours.
Parramatta Eels vs North Queensland Cowboys
Despite losing in horrible fashion to the Canberra Raiders on Sunday, it's hard to see Brad Arthur making any changes to the line-up - Moses and Cartwright remain unavailable with injuries.
However, News Corp reports that Arthur has decided to drop winger Maika Sivo from the team, with five-eighth Daejarn Asi being promoted from the NSW Cup.
This means Blaize Talagi will move back into the centres, and Bailey Simonsson will push to the wing.
Suspended for the first three rounds of the season, Sivo only made 57 running metres last week against the Raiders but did score a double during the game.
Projected Round 6 Team: 1. Clinton Gutherson 2. Bailey Simonsson 3. Will Penisini 4. Blaize Talagi 5. Sean Russell 6. Daejarn Asi 7. Dylan Brown 8. Reagan Campbell-Gillard 9. Joey Lussick 10. Junior Paulo 11. Shaun Lane 12. Kelma Tuilagi 13. J'maine Hopgood 14. Luca Moretti 15. Ryan Matterson 16. Joe Ofahengaue 17. Wiremu Greig
Todd Payten will unfortunately be forced into making a change with centre Zac Laybutt rupturing his ACL in Round 5 against the Gold Coast Titans.
This opens the door for Tom Chester, Viliami Vailea, and Semi Valemei, all of whom will contend for the vacant wing spot. Chester seems the likely choice after previously playing in the centres earlier this year.
Griffin Neame tweaked a medial, but Payten indicated that after the match, there would be no dramas and that he would be good to go for Round 6.
Projected Round 6 Team: 1. Scott Drinkwater 2. Kyle Feldt 3. Valentine Holmes 4. Tom Chester 5. Murray Taulagi 6. Tom Dearden 7. Chad Townsend 8. Jordan McLean 9. Reece Robson 10. Jason Taumalolo 11. Kulikefu Finefeuiaki 12. Jeremiah Nanai 13. Reuben Cotter 14. Jake Granville 15. Griffin Neame 16. Sam McIntyre 17. Jack Gosiewski
