Penrith centre Waqa Blake will miss his team's clash with the Wests Tigers after "misreading the training schedule," according to NRL.com.
Tyrell Fuimaono will replace Blake in the centres with utility Sione Katoa moving to lock.
Panthers lock Hame Sele has also withdrawn from the rematch against with a back complaint.
With the Panthers currently on a four-game skid, they'll be hoping to chalk up a win against Ivan Cleary's former club when they meet at Suncorp Stadium on Friday night.