New South Wales star Ryan Papenhuyzen has been ruled out of the opening Origin Series match after suffering a calf injury.

According to Michael Chammas, the Melbourne fullback won't feature for Brad Fittler's side in game one at Adelaide Oval on November 4.

โ€œLooks like Ryan Papenhuyzen has been ruled out of Origin I with a calf injury,โ€ Chammas tweeted.

โ€œWill be right for game two. Tedesco still not training with main group but 50-50. Gutherson and Cody Walker training at fullback.โ€

Papenhuyzen was set to stand in as James Tedesco's replacement from the bench, with the Roosters star also in a race against the clock to prove his fitness.